William Pardridge, M.D.
Professor of Medicine
Director of the Blood Brain Barrier Research Laboratory
13-164 Warren Hall
wpardridge@mednet.ucla.edu

Dr. Pardridge received a B.S. degree in Chemistry from UCLA in 1969, obtained an M.D. degree from Pennsylvania State University in 1974, completed internship and residency in Internal Medicine at Boston University Medical Center in 1976, was appointed Asst. Prof. of Medicine at UCLA in 1978, and was promoted to Professor of Medicine in 1985. He is certified in both Internal Medicine and the Endocrinology & Metabolism Sub-Specialty by the American Board of Internal Medicine. He is the author or editor of 5 books, and 400 articles published in the blood-brain barrier and drug targeting fields. His laboratory is presently working on new forms of gene therapy of the brain, blood-brain barrier genomics and proteomics, genetic engineering of recombinant fusion proteins, imaging gene expression in vivo with targeted antisense radiopharmaceuticals, and cloning of novel blood-brain barrier transporters.

Dr. Pardridge's laboratory research focuses on the biological basis of targeted delivery through the blood-brain barrier (BBB) of protein and gene therapeutics. Progress in this difficult area requires the merger of animal neurophysiology, pharmacokinetics, and molecular biology. The blood-brain barrier research program is devoted to developing new and non-invasive approaches to solving the brain drug delivery problem that can ultimately be used in humans. The laboratory is developing new approaches for the treatment of stroke with neurotrophins, new approaches to imaging gene expression in vivo with antisense radiopharmaceuticals, new approaches to the non-invasive, non-viral targeting of gene medicines to the brain, genetic engineering and "humanization" of monoclonal antibodies, and "BBB genomics", or the discovery of novel genes selectively expressed at the BBB.

 

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